"Train, bus, car or walk?": If you live here (backstory because it’s complicated), it comes down to where you live. Brisbane is still ironing out the public transport options in general. If you are here for travel, you might be able to get away with public transport (we have made sure that most of our suggestions above have been public transport friendly). Outside of the city, car hire will be the most reliable option and will allow for greater flexibility in outer suburbs; just keep alert but not alarmed for parking signage (fyi: our parking ticket officers take their job seriously). The central business district itself is conducive to walking but make sure that you slip, slop, slap, seek & slide (slip on a shirt, slop on the 50+ sunscreen, slap on a hat, seek shade or shelter & slide on some glasses; Australia is the melanoma capital of the world after all).
"Best accommodation?": We wouldn’t know for sure as we haven’t experienced Brisbane accommodation outside of our living quarters! In terms of luxury, Sofitel is highly rated and about as central as possible to Brisbane City. Otherwise, Airbnb it and get to know some (more likely than not) friendly locals!
"Must-see vantage point?": Mt Coot-tha Lookout offers panoramic views but is over-rated. There we go; we said it. It can also be a little bit inconvenient to get there (some advice here; parking at the top is at a premium). Our local council is currently redeveloping the Mt Coot-tha site to include a treetop canopy tour, a scenic zipline tour, & an Indigenous cultural heritage tour and skywalk. In other words, watch this space (the treetop canopy tour is expected to be open as early as sometime this year). At the base of Mt Coot-tha, however, are some very pretty gardens: we shared some of our small adventures here and here. They are really nice gardens to wander in for a few hours.
"Who is the most note-worthy person to come from your hometown?": Geoffrey Rush. Possibly? Well, he was actually born in Toowoomba (down the road and around the corner) but he went to school & university here in Brisbane so that sort of counts, yes?
"Number one thing you miss when you're away?": It is hard to beat our climate for most of the year. You thought we were going to say the Low Road Cafe. We would but they don’t offer us a highchair. :p